23 September 2021

Ennead Games

Ideas, tools, and generators to help and inspire for your games and story-telling

Random List – 20 Crazy and Bizarre Diseases

Some diseases out there that have left us completely baffled. They have mysterious origins or affect the body in ways that are completely bizarre and unexplained. The ones listed below are all real or have been documented as if they are “real”. Be warned if you decide to research further about them that some of them are rather unpleasant.  How would you integrate these into your story or game? A disgruntled alchemist could be seeking revenge for some reason or a desperate cleric is seeking a cure for one of these that is sweeping the land and all current cures are not working.

Disagree with this list? Think something else should have gone on it? Post in the comments section or on the social media platform you saw this article.

D20 Disease
1 Acute flaccid myelitis
2 Aquagenic urticaria
3 Brainerd Diarrhea
4 Creutzfeldt (Jakob disease)
5 Cyclic Vomiting Syndrome
6 Dancing plague
7 Ebola
8 Encephalitis lethargica
9 Exploding Head Syndrome
10 Gulf War Syndrome
11 Jumping Frenchmen of Maine
12 Kuru disease
13 Lujo
14 Morgellons Disease
15 Multiple Chemical Sensitivity
16 Mystery Calf Disease
17 Nodding disease
18 Peruvian Meteorite Illness
19 Porphyria disease
20 Stiff person syndrome


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